abstract：BACKGROUND:The ventricular fibrillation amplitude spectral area (AMSA) predicts whether an electrical shock could terminate ventricular fibrillation and prompt return of spontaneous circulation. We hypothesized that AMSA can guide more precise timing for effective shock delivery during cardiopulmonary resuscitation. M...

journal_title：Journal of the American Heart Association

authors： Aiello S,Perez M,Cogan C,Baetiong A,Miller SA,Radhakrishnan J,Kaufman CL,Gazmuri RJ

更新日期：2017-11-04 00:00:00

abstract：BACKGROUND:Systemic thromboxane generation, not suppressible by standard aspirin therapy and likely arising from nonplatelet sources, increases the risk of atherothrombosis and death in patients with cardiovascular disease. In the RIGOR (Reduction in Graft Occlusion Rates) study, greater nonplatelet thromboxane generat...

journal_title：Journal of the American Heart Association

authors： Kakouros N,Gluckman TJ,Conte JV,Kickler TS,Laws K,Barton BA,Rade JJ

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using hist...

journal_title：Journal of the American Heart Association

authors： Chan K,Pu X,Sandesara P,Poston RN,Simpson IA,Quyyumi AA,Ye S,Patel RS

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Novel therapies aimed at modulating the autonomic nervous system, including thoracic epidural anesthesia (TEA), have been shown in small case series to be beneficial in treating medically refractory ventricular tachycardia (VT) storm. However, it is not clear when these options should be considered. We revie...

journal_title：Journal of the American Heart Association

authors： Do DH,Bradfield J,Ajijola OA,Vaseghi M,Le J,Rahman S,Mahajan A,Nogami A,Boyle NG,Shivkumar K

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations...

journal_title：Journal of the American Heart Association

authors： Bowen TS,Brauer D,Rolim NPL,Bækkerud FH,Kricke A,Ormbostad Berre AM,Fischer T,Linke A,da Silva GJ,Wisloff U,Adams V

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the avai...

journal_title：Journal of the American Heart Association

authors： Gerber Y,Weston SA,Enriquez-Sarano M,Jaffe AS,Manemann SM,Jiang R,Roger VL

更新日期：2017-10-20 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS...

journal_title：Journal of the American Heart Association

authors： Gaye B,Tafflet M,Arveiler D,Montaye M,Wagner A,Ruidavets JB,Kee F,Evans A,Amouyel P,Ferrieres J,Empana JP

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND:Orthostatic hypotension causes ≈80 000 hospitalizations per year in the United States. Treatments for orthostatic hypotension include fludrocortisone, a mineralocorticoid analog that promotes sodium reabsorption; and midodrine, an α-1 adrenergic agonist that is a direct vasoconstrictor. Although both medicat...

journal_title：Journal of the American Heart Association

authors： Grijalva CG,Biaggioni I,Griffin MR,Shibao CA

更新日期：2017-10-12 00:00:00

abstract：BACKGROUND:Participation in cardiac rehabilitation (CR) is an essential component of care for patients with coronary artery disease. However, little is known about its benefit on cardiovascular outcomes in patients with diabetes mellitus (DM) who have undergone percutaneous coronary intervention. The aim of our study w...

journal_title：Journal of the American Heart Association

authors： Jiménez-Navarro MF,Lopez-Jimenez F,Pérez-Belmonte LM,Lennon RJ,Diaz-Melean C,Rodriguez-Escudero JP,Goel K,Crusan D,Prasad A,Squires RW,Thomas RJ

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Microvascular injury (MVI) after primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on MVI; however, there is a lack of clinical studies confirming this rela...

journal_title：Journal of the American Heart Association

authors： Reindl M,Reinstadler SJ,Feistritzer HJ,Theurl M,Basic D,Eigler C,Holzknecht M,Mair J,Mayr A,Klug G,Metzler B

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circu...

journal_title：Journal of the American Heart Association

authors： Topel ML,Hayek SS,Ko YA,Sandesara PB,Samman Tahhan A,Hesaroieh I,Mahar E,Martin GS,Waller EK,Quyyumi AA

更新日期：2017-10-03 00:00:00

abstract：:Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have repor...

journal_title：Journal of the American Heart Association

authors： Levine GN,Lange RA,Bairey-Merz CN,Davidson RJ,Jamerson K,Mehta PK,Michos ED,Norris K,Ray IB,Saban KL,Shah T,Stein R,Smith SC Jr,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nur

更新日期：2017-09-28 00:00:00

abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

journal_title：Journal of the American Heart Association

authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

更新日期：2017-09-22 00:00:00

abstract：BACKGROUND:The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS:Long QT syndrome patients aged ≥4 years trea...

journal_title：Journal of the American Heart Association

authors： Chambers KD,Beausejour Ladouceur V,Alexander ME,Hylind RJ,Bevilacqua L,Mah DY,Bezzerides V,Triedman JK,Walsh EP,Abrams DJ

更新日期：2017-09-21 00:00:00

abstract：BACKGROUND:Coronary heart disease and peripheral arterial disease (PAD) affect different vascular territories. Supplementing baseline findings with assays from stored serum, we compared their 20-year predictors. METHODS AND RESULTS:We randomly recruited 15 737 disease-free men and women aged 30 to 75 years across Scot...

journal_title：Journal of the American Heart Association

authors： Tunstall-Pedoe H,Peters SAE,Woodward M,Struthers AD,Belch JJF

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Besides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate the development of an arrhythmogenic substrate for atrial fibrillation in hypertension with and without concomitant obesity and metabolic syndrome. METHODS A...

journal_title：Journal of the American Heart Association

authors： Hohl M,Lau DH,Müller A,Elliott AD,Linz B,Mahajan R,Hendriks JML,Böhm M,Schotten U,Sanders P,Linz D

更新日期：2017-09-17 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:Thoracic endovascular aortic repair is characterized by a substantial need for reintervention. Secondary open aortic procedure becomes necessary when further endoluminal options are exhausted. This synopsis and quantitative analysis of available evidence aims to overcome the limitations of institutional coho...

journal_title：Journal of the American Heart Association

authors： Gambardella I,Antoniou GA,Torella F,Spadaccio C,Oo AY,Gaudino M,Nappi F,Shaw MA,Girardi LN

更新日期：2017-09-13 00:00:00

abstract：BACKGROUND:Troponin-T elevation is seen commonly in sepsis and septic shock patients admitted to the intensive care unit. We sought to evaluate the role of admission and serial troponin-T testing in the prognostication of these patients. METHODS AND RESULTS:This was a retrospective cohort study from 2007 to 2014 on pa...

journal_title：Journal of the American Heart Association

authors： Vallabhajosyula S,Sakhuja A,Geske JB,Kumar M,Poterucha JT,Kashyap R,Kashani K,Jaffe AS,Jentzer JC

更新日期：2017-09-09 00:00:00

abstract：BACKGROUND:Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating ...

journal_title：Journal of the American Heart Association

authors： Meeuwsen JAL,van Duijvenvoorde A,Gohar A,Kozma MO,van de Weg SM,Gijsberts CM,Haitjema S,Björkbacka H,Fredrikson GN,de Borst GJ,den Ruijter HM,Pasterkamp G,Binder CJ,Hoefer IE,de Jager SCA

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Data are limited regarding outcomes of deferred lesions in patients with angiographically insignificant stenosis but low fractional flow reserve (FFR). We investigated the natural history of angiographically insignificant stenosis with low FFR among patients who underwent routine 3-vessel FFR measurement. M...

journal_title：Journal of the American Heart Association

authors： Lee JM,Koo BK,Shin ES,Nam CW,Doh JH,Hu X,Ye F,Chen S,Yang J,Chen J,Tanaka N,Yokoi H,Matsuo H,Takashima H,Shiono Y,Hwang D,Park J,Kim KJ,Akasaka T,Wang J

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Patients receiving oral anticoagulation in addition to dual-antiplatelet therapy are known to be at high risk for bleeding events; thus, the selection of a drug-eluting stent (DES) versus a bare metal stent (BMS) can have important implications for patients with atrial fibrillation (AF) presenting with acute...

journal_title：Journal of the American Heart Association

authors： Vora AN,Wang TY,Li S,Chiswell K,Hess C,Lopes RD,Rao SV,Peterson ED

更新日期：2017-08-21 00:00:00

abstract：BACKGROUND:We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause. METHODS AND RESULTS:Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular dis...

journal_title：Journal of the American Heart Association

authors： Egelund J,Jørgensen PG,Mandrup CM,Fritz-Hansen T,Stallknecht B,Bangsbo J,Nyberg M,Hellsten Y

更新日期：2017-08-18 00:00:00

abstract：BACKGROUND:There is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (MetS) begin to be operative. Thus, we investigated the relation of age to the associations of childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness. METH...

journal_title：Journal of the American Heart Association

authors： Koskinen J,Magnussen CG,Sinaiko A,Woo J,Urbina E,Jacobs DR Jr,Steinberger J,Prineas R,Sabin MA,Burns T,Berenson G,Bazzano L,Venn A,Viikari JSA,Hutri-Kähönen N,Raitakari O,Dwyer T,Juonala M

更新日期：2017-08-16 00:00:00

abstract：BACKGROUND:Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of...

journal_title：Journal of the American Heart Association

authors： Fengler K,Ewen S,Höllriegel R,Rommel KP,Kulenthiran S,Lauder L,Cremers B,Schuler G,Linke A,Böhm M,Mahfoud F,Lurz P

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:The mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis in patients with nondiabetic advanced HF. METHODS AND RESULTS:In to...

journal_title：Journal of the American Heart Association

authors： Melenovsky V,Benes J,Franekova J,Kovar J,Borlaug BA,Segetova M,Tura A,Pelikanova T

更新日期：2017-08-07 00:00:00

abstract：BACKGROUND:Increased platelet aggregation during antiplatelet therapy may predict cardiovascular events in patients with coronary artery disease. The majority of these patients receive aspirin monotherapy. We aimed to investigate whether high platelet-aggregation levels predict cardiovascular events in stable coronary ...

journal_title：Journal of the American Heart Association

authors： Larsen SB,Grove EL,Neergaard-Petersen S,Würtz M,Hvas AM,Kristensen SD

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:The MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted-type MMPs, a member of the membrane-type MMP family, MT1-MMP (membrane-type 1 MMP; MMP14), mediates pericellular extracellular matrix degradation that is indisp...

journal_title：Journal of the American Heart Association

authors： Barnes RH 2nd,Akama T,Öhman MK,Woo MS,Bahr J,Weiss SJ,Eitzman DT,Chun TH

更新日期：2017-07-22 00:00:00

abstract：BACKGROUND:Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among individuals with low (<130 mg/dL) LDL cholesterol, we undertook detail...

journal_title：Journal of the American Heart Association

authors： Lawler PR,Akinkuolie AO,Chu AY,Shah SH,Kraus WE,Craig D,Padmanabhan L,Glynn RJ,Ridker PM,Chasman DI,Mora S

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS:Participants in t...

journal_title：Journal of the American Heart Association

authors： Wilner B,Garg S,Ayers CR,Maroules CD,McColl R,Matulevicius SA,de Lemos JA,Drazner MH,Peshock R,Neeland IJ

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is ...

journal_title：Journal of the American Heart Association

authors： Kontos A,Lushington K,Martin J,Schwarz Q,Green R,Wabnitz D,Xu X,M Sokoya E,Willoughby S,Baumert M,Ferrante A,La Forgia M,Kennedy D

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

journal_title：Journal of the American Heart Association

authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, it is important to investigate the specific regulatory pathways that act...

journal_title：Journal of the American Heart Association

authors： Jiang D,Zhuang J,Peng W,Lu Y,Liu H,Zhao Q,Chi C,Li X,Zhu G,Xu X,Yan C,Xu Y,Ge J,Pang J

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone deacetylase 1 (HDAC1) ...

journal_title：Journal of the American Heart Association

authors： Moore JB 4th,Zhao J,Fischer AG,Keith MCL,Hagan D,Wysoczynski M,Bolli R

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor-κB is a nuclear transcription factor activated post-ischemia, responsible for the transcription of proinflammatory proteins. The role of nuclear factor-κB in the renal fibrosis post-AKI is unknown. ...

journal_title：Journal of the American Heart Association

authors： Johnson FL,Patel NSA,Purvis GSD,Chiazza F,Chen J,Sordi R,Hache G,Merezhko VV,Collino M,Yaqoob MM,Thiemermann C

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Previous studies have documented a high prevalence of atrial fibrillation (AF) in individuals with obstructive sleep apnea (OSA). Central sleep apnea (CSA) has been associated with AF in patients with heart failure. However, data from prospective cohorts are sparse and few studies have distinguished the asso...

journal_title：Journal of the American Heart Association

authors： Tung P,Levitzky YS,Wang R,Weng J,Quan SF,Gottlieb DJ,Rueschman M,Punjabi NM,Mehra R,Bertisch S,Benjamin EJ,Redline S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Diagnosis of atrial fibrillation (AF) can be difficult, requiring cumbersome investigations. We aimed to determine the association of established whole-blood gene expression scores with prevalent AF and to evaluate their performance for the identification of AF in a SIRS (Steroids in Cardiac Surgery) trial c...

journal_title：Journal of the American Heart Association

authors： Thériault S,Whitlock R,Raman K,Vincent J,Yusuf S,Paré G

更新日期：2017-06-30 00:00:00

abstract：BACKGROUND:The aim of our study was to evaluate the relationship of pulse pressure (PP), a raw index of arterial stiffness, with noninvasively determined coronary flow reserve (CFR) and its components, in patients with angiographically normal epicardial coronary arteries. METHODS AND RESULTS:The study population inclu...

journal_title：Journal of the American Heart Association

authors： Lembo M,Sicari R,Esposito R,Rigo F,Cortigiani L,Lo Iudice F,Picano E,Trimarco B,Galderisi M

更新日期：2017-06-29 00:00:00